| NCT07225582 | Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia | Case Western Reserve University | | - Age 22 - 65 yrs
- Level C1-T1
AIS - All
- have already been enrolled in the in the "Reconnecting the Hand and Arm to the Brain (ReHAB)" Study (NCT03898804)
| Recruiting | 3 | NA | Technology | Arm/hand function | | 2 years | 01 January 2026 | 06 November 2025 | 1 | |
| NCT07224256 | VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration | Neuralink Corp | | - Age 22 - 75 yrs
- Level C1-S5
AIS - All
| Recruiting | 6 | NA | Technology | General health | | 2 years | 03 October 2025 | 04 November 2025 | 1 | |
| NCT06808035 | Understanding Perinatal Spinal Cord Injury | University of Louisville | | - Age 3 - 8 yrs
- Level C1-C8
AIS - All
- NOT currently use a baclofen pump
- be diagnosed with a perinatal (injured in utero or at birth) spinal cord injury
| By invitation | 6 | NA | Technology | General health | - Box and Block Test (BBT)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Neurogenic Bowel Dysfunction Score (NBD or NBDS)
- Neuromuscular Recovery Scale
- Pendulum Test (Wartenberg)
- Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)
- Surface Electromyography (sEMG)
| 2 months | 09 January 2024 | 05 February 2025 | 1 | |
| NCT06974968 | Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | | - Age 18 - 65 yrs
- Level C4-L2
AIS A, B, C- 14 days - 60 days
| Recruiting soon | 60 | PHASE2 | Biological/cell based | General health | - Adverse Events (AEs)
- American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Spinal Cord Independence Measure (SCIM)
| 1 year | 25 May 2028 | 16 May 2025 | 1 | |
| NCT07007884 | Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord Injury | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | | - Age 18 - 60 yrs
- Level C1-S5
AIS - ≥ 6 months
- NOT have a cardiac or neural pacemaker
- have history of autonomic dysreflexia
- cervical spinal cord injury
- Diagnosed with cauda equina syndrome
| Recruiting | 30 | NA | Technology | General health | - Blood Pressure and Heart Rate Regulation
| 11 days | 20 March 2024 | 06 June 2025 | 2 | |
| NCT07106060 | Near-Infrared Imaging of Motor Imagery Effects in Spinal Cord Injury | Shengjing Hospital | | - Age 18 - 75 yrs
- Level C5-T12
AIS A, B, C- ≤ 12 months
| Recruiting | 36 | NA | Technology | General health | - American Spinal Injury Association Impairment Scale (AIS): International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Barthel Index (BI)
| 4 weeks | 01 January 2025 | 06 August 2025 | 1 | |
