| NCT06813287 | Brain Monitoring, tDCS and Robotic Training in SCI | Burke Medical Research Institute | | - Age 16 - 65 yrs
- Level C5-T1
AIS - ≥ 6 months
- NOT have metal inside the skull (other than dental appliances or fillings) that may pose a physical hazard during magnetic stimulation
| Ended | 17 | PHASE2 | Technology | General health | - Action Research Arm Test (ARAT)
- American Spinal Injury Association Impairment Scale (AIS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Jebsen Hand Function Test (JHFT)
- Motor Evoked Potentials (MEPs)
- Pain Visual Analog Scale (VAS)
- Quadriplegia Index of Function (QIF)
- Spinal Cord Independence Measure (SCIM)
| 1 month | 01 November 2012 | 06 February 2025 | 1 | |
| NCT06815601 | Neuromodulation After Spinal Cord Injury to Improve Limb Function | State University of New York at Buffalo | | - Age 18 - 75 yrs
- Level C1-S5
AIS - All
- NOT have a metal plate in the skull
| Recruiting | 60 | NA | Technology | Arm/hand function | - Motor Evoked Potentials (MEPs)
- Surface Electromyography (sEMG)
| 20 weeks | 10 April 2025 | 07 February 2025 | 1 | |
| NCT06831240 | New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI) | Nova Scotia Health Authority | | - Age ≥ 18 yrs
- Level C1-S5
AIS - All
- be wheelchair users
| Recruiting soon | 150 | | | General health | | 1 year | 15 April 2025 | 18 February 2025 | 1 | |
| NCT06839300 | The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study | AO Foundation, AO Spine | | - Age ≥ 19 yrs
- Level C1-L1
AIS A, B, C, D- ≤ 24 null
- NOT have a penetrating SCI (eg, gunshot, stab)
| Recruiting | 260 | | | General health | - American Spinal Injury Association Impairment Scale (AIS)
- International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)
- Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative
- Serum Biomarker
| 1 year | 09 February 2026 | 21 February 2025 | 8 | |
| NCT06274021 | Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury | University of Mississippi Medical Center | | - Age ≥ 18 yrs
- Level C1-T11
AIS - ≥ 6 months
- NOT have an implanted active devices
- NOT have passive implants (plates, screws) below the level of injury
- HAVE presence of spasticity in the lower limbs
| Recruiting | 16 | EARLY_PHASE1 | Technology | Spasticity | - Ashworth and Modified Ashworth Scale (MAS)
- Spinal Cord Assessment Tool for Spastic Reflexes (SCATS)
| 5 weeks | 01 March 2024 | 23 February 2024 | 2 | |
| NCT05965700 | NVG-291 in Spinal Cord Injury Subjects | NervGen Pharma | | - Age 18 - 75 yrs
- Level C1-C8
AIS B, C, D- 20 days - 90 days
- NOT have a spinal cord injury due to gunshot wound or penetrating injury
- NOT have an implanted device in the brain or spinal cord
- NOT have an implanted pacemaker
- be able to volitionally initiate at least one step (without body weight support
| Recruiting | 40 | PHASE1, PHASE2 | Drug | Standing/walking/mobility | - 10 Meter Walking Test (10 MWT)
- Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)
- Hand-Held Myometery / Dynamometry
- Motor evoked potential
| 16 weeks | 08 August 2023 | 28 July 2023 | 1 | |
