Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy

Drug
General health
Online since 20 January 2026, updated today

About this trial

This trial is enrolling 16 participants previously treated with an experimental bladder drug to assess its long-term safety and tolerability. The drug, EG110A, is being studied for its effects on bladder function in people with spinal cord injury, with the aim of reducing involuntary bladder muscle contractions. If included, participants will continue follow-up after completion or early discontinuation of a prior EG110A clinical study (NCT06596291). Final testing of long-term safety will be performed after 5 years.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C1 - L5
Time since injury
≥ 1 year
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C1-L5
    Additionally, participants must
    have received at least one dose/injection of EG110A in Study EG110A-001-01 (NCT06596291: https://www.scitrialsfinder.net/trials/NCT06596291)

    What’s involved

    Type

    Drug

    Details

    - Participants will continue follow-up after completion or early discontinuation of a prior EG110A clinical study (NCT06596291). - EG110A is an investigational drug being studied for its effects on bladder function in people with spinal cord injury, with the aim of reducing involuntary bladder muscle contractions. - Final testing of long-term safety will be performed after 5 years.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Bladder health/function

    Mental health and psychosocial factors

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more


    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Apr 2026
    • Organisation
    • EG 427
    • Trial recruitment status
    • Recruiting soon
    • Trial start date
    • 1 Apr 2026
    • Organisation
    • EG 427

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more