{
    "componentChunkName": "component---src-templates-trial-trial-js",
    "path": "/trials/NCT02144558",
    "result": {"pageContext":{"pagePath":"/trials/NCT02144558","trial":{"nct_id":"NCT02144558","brief_title":"Fertility of Spinal Cord Injured Men","official_title":"Evolution of Sperm Parameters and Study of Risk Factors of Impairment of Sperm Quality in Spinal Cord Injuries. Longitudinal Prospective Study.","about_trial":"Spinal cord injured (SCI) men, para or tetraplegic, most often have an infertility, caused among others by a deficiency of sperm quality particularly motility and vitality. Several mechanisms have been proposed: low frequency of ejaculation, recurrent urinary tract and seminal infections, presence of an inflammatory syndrome (IS) and an oxidative stress (OS). However, no French study of sperm quality has been conducted in this population that could identify aggravating factors of sperm quality and a way to prevent them.\n\nHypothesis: Sperm parameters decrease rapidly following spinal cord injury and next stabilise. However, unidentified yet risk factors could influence long-term evolution of sperm parameters.\n\nThe objective is to study the evolution of sperm parameters during 18 months taking into account bladder management, recurrent urinary tract and bladder infections, IS and OS. The evaluation of these parameters and their consequences will be indicative to determine one or more risk factors of sperm degradation and determine a strategy for long term support to avoid the use of ART either by sperm cryopreservation and/or by preventing risk factors","age_from":18,"age_to":60,"ais_a":true,"ais_b":true,"ais_c":true,"ais_d":true,"ais_e":null,"time_since_injury_from":0,"time_since_injury_from_unit":"hours","time_since_injury_to":0,"time_since_injury_to_unit":"hours","healthy_volunteers":false,"inclusion_criteria":null,"study_type":"interventional","allocation":"N/A","brief_description":"Spinal cord injured (SCI) men, para or tetraplegic, most often have an infertility, caused among others by a deficiency of sperm quality particularly motility and vitality. Several mechanisms have been proposed: low frequency of ejaculation, recurrent urinary tract and seminal infections, presence of an inflammatory syndrome (IS) and an oxidative stress (OS). However, no French study of sperm quality has been conducted in this population that could identify aggravating factors of sperm quality and a way to prevent them.\n\nHypothesis: Sperm parameters decrease rapidly following spinal cord injury and next stabilise. However, unidentified yet risk factors could influence long-term evolution of sperm parameters.\n\nThe objective is to study the evolution of sperm parameters during 18 months taking into account bladder management, recurrent urinary tract and bladder infections, IS and OS. The evaluation of these parameters and their consequences will be indicative to determine one or more risk factors of sperm degradation and determine a strategy for long term support to avoid the use of ART either by sperm cryopreservation and/or by preventing risk factors","detailed_description":null,"final_testing_performed":null,"version_id":1,"emsci_trial":false,"curation_status":"uncurated","overall_recruitment_status":"ended","primary_intervention":null,"primary_benefit":{"id":9,"name":"Sexual health","parent_id":null,"icon_name":"love-heart"},"sex":"Male","injury_level_from":"C1","injury_level_to":"S5","start_date":"2014-04-24","organization":"Assistance Publique - Hôpitaux de Paris","benefits":[{"id":5,"name":"General health","parent_id":null,"icon_name":"general-health"},{"id":9,"name":"Sexual health","parent_id":null,"icon_name":"love-heart"}],"injuries":[{"id":3,"name":"Traumatic","parent_id":1,"pivot":{"trial_id":854,"injury_id":3}}],"interventions":[],"outcome_measures":[],"recovery_mechanisms":[],"published_at":"2024-04-16T22:20:58.000000Z","modified_at":"2024-04-16T22:20:58.000000Z"},"layout":"trial"}},
    "staticQueryHashes": ["1748999444"]}